[HTML][HTML] Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2
H Le Stunff, P Giussani, M Maceyka, S Lépine… - Journal of biological …, 2007 - ASBMB
In yeast, the long-chain sphingoid base phosphate phosphohydrolase Lcb3p is required for
efficient ceramide synthesis from exogenous sphingoid bases. Similarly, in this study, we
found that incorporation of exogenous sphingosine into ceramide in mammalian cells was
regulated by the homologue of Lcb3p, sphingosine-1-phosphate phosphohydrolase 1 (SPP-
1), an endoplasmic reticulum resident protein. Sphingosine incorporation into endogenous
long-chain ceramides was increased by SPP-1 overexpression, whereas recycling of C 6 …
efficient ceramide synthesis from exogenous sphingoid bases. Similarly, in this study, we
found that incorporation of exogenous sphingosine into ceramide in mammalian cells was
regulated by the homologue of Lcb3p, sphingosine-1-phosphate phosphohydrolase 1 (SPP-
1), an endoplasmic reticulum resident protein. Sphingosine incorporation into endogenous
long-chain ceramides was increased by SPP-1 overexpression, whereas recycling of C 6 …