[HTML][HTML] Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like …
P Gurung, RKS Malireddi, PK Anand, D Demon… - Journal of Biological …, 2012 - ASBMB
Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like
receptor (TLR) and inflammasome signaling are critical for host responses against these
pathogens, but how these pathways are integrated remains unclear. Here, we show that
TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages
infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast,
TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 …
receptor (TLR) and inflammasome signaling are critical for host responses against these
pathogens, but how these pathways are integrated remains unclear. Here, we show that
TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages
infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast,
TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 …