Central roles of NLRs and inflammasomes in viral infection
TD Kanneganti - Nature Reviews Immunology, 2010 - nature.com
Nature Reviews Immunology, 2010•nature.com
The immune response to viral infections is determined by a complex interplay between the
pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral
infection. Recognition by these sensors induces the production of type I interferons and the
assembly of inflammasome complexes that activate caspase-1, leading to production of
interleukin-1β (IL-1β) and IL-18. Here, I discuss recent progress in our understanding of the
central roles of NOD-like receptors (NLRs) and inflammasomes in the immune response …
pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral
infection. Recognition by these sensors induces the production of type I interferons and the
assembly of inflammasome complexes that activate caspase-1, leading to production of
interleukin-1β (IL-1β) and IL-18. Here, I discuss recent progress in our understanding of the
central roles of NOD-like receptors (NLRs) and inflammasomes in the immune response …
Abstract
The immune response to viral infections is determined by a complex interplay between the pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral infection. Recognition by these sensors induces the production of type I interferons and the assembly of inflammasome complexes that activate caspase-1, leading to production of interleukin-1β (IL-1β) and IL-18. Here, I discuss recent progress in our understanding of the central roles of NOD-like receptors (NLRs) and inflammasomes in the immune response during viral infections. This information will improve our understanding of host defence mechanisms against viruses and provide new avenues for interfering in the pathogenesis of infectious diseases.
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