[HTML][HTML] Mitochondrial dysfunction in congenital nephrotic syndrome
ML Solin, S Pitkänen, JW Taanman, H Holthöfer - Laboratory investigation, 2000 - Elsevier
The molecular mechanisms maintaining the kidney glomerular filtration barrier remain
poorly understood. Recent evidence suggests that mitochondrial dysfunction is a
characteristic feature of kidney glomeruli in congenital nephrotic syndrome of the Finnish
type (CNF). Here we searched for detailed functional evidence of mitochondrial lesion in
CNF kidneys. We used histochemical and immunohistochemical methods, quantitative
measurement of mitochondrial DNA, and superoxide production to characterize the …
poorly understood. Recent evidence suggests that mitochondrial dysfunction is a
characteristic feature of kidney glomeruli in congenital nephrotic syndrome of the Finnish
type (CNF). Here we searched for detailed functional evidence of mitochondrial lesion in
CNF kidneys. We used histochemical and immunohistochemical methods, quantitative
measurement of mitochondrial DNA, and superoxide production to characterize the …