Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis

B Smeets, C Kuppe, EM Sicking, A Fuss… - Journal of the …, 2011 - journals.lww.com
The pathogenesis of the development of sclerotic lesions in focal segmental
glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or
parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three
distinct models of FSGS (5/6-nephrectomy+ DOCA-salt; the murine transgenic chronic Thy1.
1 model; or the MWF rat) and in human biopsies, the primary injury to induce FSGS
associated with focal activation of PECs and the formation of cellular adhesions to the …