[HTML][HTML] Regulation and function of SUMO modification
RS Hilgarth, LA Murphy, HS Skaggs… - Journal of Biological …, 2004 - ASBMB
Small ubiquitin-like modifier (SUMO) 1 is a protein of 97 amino acids that is structurally
similar to ubiquitin and has been called by other names including Smt3p, Pmt2p, PIC-1,
GMP1, Ubl1, and Sentrin (1). Like ubiquitin, SUMO has been found to be covalently attached
to certain lysine residues of specific target proteins (2). In contrast to ubiquitination, however,
sumoylation does not promote the degradation of proteins but instead alters a number of
different functional parameters of proteins, depending on the protein substrate in question …
similar to ubiquitin and has been called by other names including Smt3p, Pmt2p, PIC-1,
GMP1, Ubl1, and Sentrin (1). Like ubiquitin, SUMO has been found to be covalently attached
to certain lysine residues of specific target proteins (2). In contrast to ubiquitination, however,
sumoylation does not promote the degradation of proteins but instead alters a number of
different functional parameters of proteins, depending on the protein substrate in question …