[HTML][HTML] Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells
AL Kim, AJ Raffo, PW Brandt-Rauf, MR Pincus… - Journal of Biological …, 1999 - ASBMB
A p53-derived C-terminal peptide induced rapid apoptosis in breast cancer cell lines
carrying endogenous p53 mutations or overexpressed wild-type (wt) p53 but was not toxic to
nonmalignant human cell lines containing wt p53. Apoptosis occurred through a Fas/APO-1
signaling pathway involving increased extracellular levels of Fas/FasL in the absence of
protein synthesis, as well as activation of a Fas/APO-1-specific protease, FLICE. The peptide
activity was p53-dependent, and it had no effect in three tumor cell lines with null p53 …
carrying endogenous p53 mutations or overexpressed wild-type (wt) p53 but was not toxic to
nonmalignant human cell lines containing wt p53. Apoptosis occurred through a Fas/APO-1
signaling pathway involving increased extracellular levels of Fas/FasL in the absence of
protein synthesis, as well as activation of a Fas/APO-1-specific protease, FLICE. The peptide
activity was p53-dependent, and it had no effect in three tumor cell lines with null p53 …