Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse
FA Schroeder, CL Lin, WE Crusio, S Akbarian - Biological psychiatry, 2007 - Elsevier
BACKGROUND: Chromatin remodeling, including changes in histone acetylation, might
play a role in the pathophysiology and treatment of depression. We investigated whether the
histone deacetylase inhibitor sodium butyrate (SB) administered as single drug or in
combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine exerts
antidepressant-like effects in mice. METHODS: Mice (C57BL/6J) received injections of SB,
fluoxetine, or a combination of both drugs either acutely or chronically for a period of 28 days …
play a role in the pathophysiology and treatment of depression. We investigated whether the
histone deacetylase inhibitor sodium butyrate (SB) administered as single drug or in
combination with the selective serotonin reuptake inhibitor (SSRI) fluoxetine exerts
antidepressant-like effects in mice. METHODS: Mice (C57BL/6J) received injections of SB,
fluoxetine, or a combination of both drugs either acutely or chronically for a period of 28 days …