Highlights•The gut microbiota interacts with enteroendocrine cells.•SCFAs triggers gut
peptide secretion through GPR43-dependent and GPR41-dependent mechanisms.•The gut
microbiota links the endocannabinoid system to L cell functions.•A. muciniphila interacts with
enteroendocrine cells to modulate gut barrier function.•Several GPCRs expressed on
intestinal L cells may constitute putative therapeutic targets.The gut microbiota affects host
metabolism through a number of physiological processes. Emerging evidence suggests that …