Enteric gliopathy in niacin-deficiency induced by CNS glio-toxin
H Aikawa, K Suzuki - Brain research, 1985 - Elsevier
H Aikawa, K Suzuki
Brain research, 1985•ElsevierAminonicotinamide (6-AN), an antagonist of niacin and a potent CNS glio-toxin, selectively
caused degeneration of glial cells in the central nervous system (CNS) of rodents. Suckling
mice treated with 6-AN developed diarrhea clinically and displayed vacuolated
degenerating glial cells in the myenteric plexus as well as in the CNS. Myenteric neurons
were well preserved. These findings provide further evidence for possible functional
similarities between the glial cells in the central and enteric nervous systems.
caused degeneration of glial cells in the central nervous system (CNS) of rodents. Suckling
mice treated with 6-AN developed diarrhea clinically and displayed vacuolated
degenerating glial cells in the myenteric plexus as well as in the CNS. Myenteric neurons
were well preserved. These findings provide further evidence for possible functional
similarities between the glial cells in the central and enteric nervous systems.
Abstract
6-Aminonicotinamide (6-AN), an antagonist of niacin and a potent CNS glio-toxin, selectively caused degeneration of glial cells in the central nervous system (CNS) of rodents. Suckling mice treated with 6-AN developed diarrhea clinically and displayed vacuolated degenerating glial cells in the myenteric plexus as well as in the CNS. Myenteric neurons were well preserved. These findings provide further evidence for possible functional similarities between the glial cells in the central and enteric nervous systems.
Elsevier