HELIOS-BCL11B fusion gene involvement in at (2; 14)(q34; q32) in an adult T-cell leukemia patient
R Fujimoto, T Ozawa, T Itoyama, N Sadamori… - Cancer genetics, 2012 - Elsevier
To provide fundamental insights into the leukemogenesis of adult T-cell leukemia/lymphoma
(ATLL), we performed a molecular analysis of the chromosomal abnormalities in one ATLL
case with a novel reciprocal translocation: t (2; 14)(q34; q32). Using fluorescence in situ
hybridization with cosmid probes derived from the 14q32 region, we characterized the
rearranged 14q32 allele. Molecular cloning of the breakpoint revealed that the reciprocal
translocation fused the 5′ proximal region of the B-cell lymphoma 11B (BCL11B) gene …
(ATLL), we performed a molecular analysis of the chromosomal abnormalities in one ATLL
case with a novel reciprocal translocation: t (2; 14)(q34; q32). Using fluorescence in situ
hybridization with cosmid probes derived from the 14q32 region, we characterized the
rearranged 14q32 allele. Molecular cloning of the breakpoint revealed that the reciprocal
translocation fused the 5′ proximal region of the B-cell lymphoma 11B (BCL11B) gene …