Effects of mid-jejunal compared to duodenal glucose infusion on peptide hormone release and appetite in healthy men
R Chaikomin, KL Wu, S Doran, JH Meyer, KL Jones… - Regulatory peptides, 2008 - Elsevier
INTRODUCTION: Cells containing GIP and CCK predominate in the upper small intestine,
while those containing GLP-1 are located more distally. Our aim was to compare the
hormonal, glycemic and appetite responses to different sites of glucose delivery. METHODS:
Ten healthy males were each studied twice, in randomized order. A catheter was positioned
with openings 15 cm beyond the pylorus (“duodenal”), and 100 cm beyond (“mid-jejunal”).
On one day, glucose was infused into the duodenum (1 kcal/min) and saline into the mid …
while those containing GLP-1 are located more distally. Our aim was to compare the
hormonal, glycemic and appetite responses to different sites of glucose delivery. METHODS:
Ten healthy males were each studied twice, in randomized order. A catheter was positioned
with openings 15 cm beyond the pylorus (“duodenal”), and 100 cm beyond (“mid-jejunal”).
On one day, glucose was infused into the duodenum (1 kcal/min) and saline into the mid …