Calcitonin gene-related peptide potently stimulates glucagon-like peptide-1 release in the isolated perfused rat ileum
C Herrmann–Rinke, GP McGregor, B Göke - Peptides, 2000 - Elsevier
The post-prandial release of glucagon-like peptide-1 (GLP-1) from the distal gut appears to
involve a neural reflex that arises from the proximal gut. The neuropeptide calcitonin gene-
related peptide (CGRP)'s potent stimulatory effect on GLP-1 release was characterized,
using the isolated vascularly perfused rat ileum. CGRP, but not its homolog amylin, induced
a dose-dependent and sustained release of GLP-1. This effect was greatly reduced in the
presence of CGRP (8–37), was abolished by galanin, potentiated by luminal glucose and …
involve a neural reflex that arises from the proximal gut. The neuropeptide calcitonin gene-
related peptide (CGRP)'s potent stimulatory effect on GLP-1 release was characterized,
using the isolated vascularly perfused rat ileum. CGRP, but not its homolog amylin, induced
a dose-dependent and sustained release of GLP-1. This effect was greatly reduced in the
presence of CGRP (8–37), was abolished by galanin, potentiated by luminal glucose and …