[HTML][HTML] Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in …
Extracellular matrix (ECM) composition, organization, and compliance provide both
architectural and chemical cues that modulate tissue structure and function. ECM produced
by stromal fibroblasts plays a key role in breast cancer invasion and metastasis, which are
also stimulated by intratumoral hypoxia. Here, we demonstrate that hypoxia-inducible factor
1 (HIF-1) is a critical regulator of ECM remodeling by fibroblasts under hypoxic conditions.
HIF-1 activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl …
architectural and chemical cues that modulate tissue structure and function. ECM produced
by stromal fibroblasts plays a key role in breast cancer invasion and metastasis, which are
also stimulated by intratumoral hypoxia. Here, we demonstrate that hypoxia-inducible factor
1 (HIF-1) is a critical regulator of ECM remodeling by fibroblasts under hypoxic conditions.
HIF-1 activates expression of genes encoding collagen prolyl (P4HA1 and P4HA2) and lysyl …