[HTML][HTML] Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
RM Vabulas, P Ahmad-Nejad, C da Costa… - Journal of Biological …, 2001 - ASBMB
Heat shock proteins (HSPs) require no adjuvant to confer immunogenicity to bound
peptides, as if they possessed an intrinsic" danger" signature. To understand the
proinflammatory nature of HSP, we analyzed signaling induced by human and chlamydial
HSP60. We show that both HSP60s activate the stress-activated protein kinases p38 and
JNK1/2, the mitogen-activated protein kinases ERK1/2, and the I-κB kinase (IKK). Activation
of JNK and IKK proceeds via the Toll/IL-1 receptor signaling pathway involving MyD88 and …
peptides, as if they possessed an intrinsic" danger" signature. To understand the
proinflammatory nature of HSP, we analyzed signaling induced by human and chlamydial
HSP60. We show that both HSP60s activate the stress-activated protein kinases p38 and
JNK1/2, the mitogen-activated protein kinases ERK1/2, and the I-κB kinase (IKK). Activation
of JNK and IKK proceeds via the Toll/IL-1 receptor signaling pathway involving MyD88 and …