[HTML][HTML] Constitutive association of MyD88 to IRAK in HTLV-I–transformed T cells
T Mizobe, J Tsukada, T Higashi, F Mouri… - Experimental …, 2007 - Elsevier
OBJECTIVE: Constitutive activation of nuclear factor (NF)-κB is a common feature of human
T-cell leukemia virus type I (HTLV-I)–transformed T cells. Inhibition of NF-κB activity reduces
cell growth and induces apoptosis of HTLV-I–transformed T cells, suggesting a central role
of NF-κB in their proliferation and survival. In this study, we investigated whether MyD88, an
adaptor protein of Toll-like receptor (TLR) signaling, contributes to constitutive NF-κB
activation in HTLV-I–transformed T cells. MATERIALS AND METHODS: Activation status of …
T-cell leukemia virus type I (HTLV-I)–transformed T cells. Inhibition of NF-κB activity reduces
cell growth and induces apoptosis of HTLV-I–transformed T cells, suggesting a central role
of NF-κB in their proliferation and survival. In this study, we investigated whether MyD88, an
adaptor protein of Toll-like receptor (TLR) signaling, contributes to constitutive NF-κB
activation in HTLV-I–transformed T cells. MATERIALS AND METHODS: Activation status of …