[HTML][HTML] The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline …
S Mukherjee, O Cruz-Rodríguez, E Bolton… - Journal of Biological …, 2012 - ASBMB
The androgen receptor (AR) mediates the effects of male sexual hormones on development
and physiology. Alterations in AR function are central to reproductive disorders, prostate
cancer, and Kennedy disease. AR activity is influenced by post-translational modifications,
but their role in AR-based diseases is poorly understood. Conjugation by small ubiquitin-like
modifier (SUMO) proteins at two synergy control (SC) motifs in AR exerts a promoter context-
dependent inhibitory role. SC motifs are composed of a four-amino acid core that is often …
and physiology. Alterations in AR function are central to reproductive disorders, prostate
cancer, and Kennedy disease. AR activity is influenced by post-translational modifications,
but their role in AR-based diseases is poorly understood. Conjugation by small ubiquitin-like
modifier (SUMO) proteins at two synergy control (SC) motifs in AR exerts a promoter context-
dependent inhibitory role. SC motifs are composed of a four-amino acid core that is often …