Quest for safety at AAValon

E Montini - Blood, The Journal of the American Society of …, 2011 - ashpublications.org
E Montini
Blood, The Journal of the American Society of Hematology, 2011ashpublications.org
In this issue of Blood, Li and colleagues show an exhaustive, long-term safety assessment of
adeno-associated virus (AAV) vector integration in mouse liver. 1 Massive amounts of
histopathologic, vector integration, and transcriptomic data provide a highly detailed view of
the genomic impact of AAV vector integration in vivo. AAV vector integrations are not
associated with tumor formation in these settings.
In this issue of Blood, Li and colleagues show an exhaustive, long-term safety assessment of adeno-associated virus (AAV) vector integration in mouse liver. 1 Massive amounts of histopathologic, vector integration, and transcriptomic data provide a highly detailed view of the genomic impact of AAV vector integration in vivo. AAV vector integrations are not associated with tumor formation in these settings.
ashpublications.org