Glucose disposal induces a signal that modulates the transcriptional regulation of genes
involved in the glycolysis and lipogenesis pathways. To investigate the role of glucose
metabolism on hepatic gene expression independently from insulin action, we
overexpressed glucokinase, the limiting enzyme in the glycolysis pathway, in the liver of
streptozotocin-induced type 1 diabetic rats. By microarray analysis, we observed that critical
genes such as liver-type pyruvate kinase, malic enzyme, fatty acid synthase, and stearoyl …