Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia
C Karcher, A Fischer, A Schweickert, E Bitzer, S Horie… - Differentiation, 2005 - Elsevier
The invariant asymmetric placement of thoracic and abdominal organs in the vertebrates is
controlled by the left-asymmetric activity of the Nodal signaling cascade during
embryogenesis. In the mouse embryo asymmetric induction of nodal is thought to be
dependent on functional monocilia on the ventral node cells and on the Pkd2 gene, which
encodes the calcium channel polycystin-2 (PC2). In humans mutations in PKD2 and PKD1
give rise to polycystic kidney disease. The PC1 and PC2 proteins are thought to function as …
controlled by the left-asymmetric activity of the Nodal signaling cascade during
embryogenesis. In the mouse embryo asymmetric induction of nodal is thought to be
dependent on functional monocilia on the ventral node cells and on the Pkd2 gene, which
encodes the calcium channel polycystin-2 (PC2). In humans mutations in PKD2 and PKD1
give rise to polycystic kidney disease. The PC1 and PC2 proteins are thought to function as …