[HTML][HTML] The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
N Liu, H Li, S Li, M Shen, N Xiao, Y Chen… - Journal of biological …, 2010 - ASBMB
The proproliferative transcription factor KLF5 plays an important role in promoting cell
proliferation and tumorigenesis. KLF5 is a short-lived protein that can be rapidly degraded
through the ubiquitin-proteasome pathway in cancer cells. However, the mechanisms
regulating protein stability remain poorly understood. In this study, the tumor suppressor
Fbw7, a component of the SCF complex (SCF Fbw7) E3 ubiquitin ligase, specifically
promoted the degradation and ubiquitination of KLF5 but had little effect on the stability of …
proliferation and tumorigenesis. KLF5 is a short-lived protein that can be rapidly degraded
through the ubiquitin-proteasome pathway in cancer cells. However, the mechanisms
regulating protein stability remain poorly understood. In this study, the tumor suppressor
Fbw7, a component of the SCF complex (SCF Fbw7) E3 ubiquitin ligase, specifically
promoted the degradation and ubiquitination of KLF5 but had little effect on the stability of …