[HTML][HTML] Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
N Gupta-Rossi, O Le Bail, H Gonen, C Brou… - Journal of Biological …, 2001 - ASBMB
The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well
as in vertebrates. After ligand binding, a two-step proteolytic cleavage releases the
intracellular part of the receptor which translocates to the nucleus and acts as a
transcriptional activator. Although Notch-induced transcription of genes has been reported
extensively, its endogenous nuclear form has been seldom visualized. We report that the
nuclear intracellular domain of Notch1 is stabilized by proteasome inhibitors and is a …
as in vertebrates. After ligand binding, a two-step proteolytic cleavage releases the
intracellular part of the receptor which translocates to the nucleus and acts as a
transcriptional activator. Although Notch-induced transcription of genes has been reported
extensively, its endogenous nuclear form has been seldom visualized. We report that the
nuclear intracellular domain of Notch1 is stabilized by proteasome inhibitors and is a …