5′ Deiodinase activity in brain regions of adult rats: modifications in different situations of experimental hypothyroidism
A Serrano-Lozano, M Montiel, M Morell, P Morata - Brain research bulletin, 1993 - Elsevier
In the central nervous system, type II 5′ deiodinase (5′ D-II) is highly regulated, as judged
by the dramatic changes in enzyme levels observed after abrupt alterations in thyroid status.
In this work, the 5'-DII activity has been studied in different situations of experimental
hypothyroidism (propylthiouracil, methimazole, thyroidectomy, and low iodine diet), in
various brain regions (pituitary, cerebellum, brain stem, hypothalamus, cortex, and whole
brain) in adult rats. Propylthiouracil and methimazole significantly increase the activity in all …
by the dramatic changes in enzyme levels observed after abrupt alterations in thyroid status.
In this work, the 5'-DII activity has been studied in different situations of experimental
hypothyroidism (propylthiouracil, methimazole, thyroidectomy, and low iodine diet), in
various brain regions (pituitary, cerebellum, brain stem, hypothalamus, cortex, and whole
brain) in adult rats. Propylthiouracil and methimazole significantly increase the activity in all …