Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome
M Cerrone, M Delmar - Trends in cardiovascular medicine, 2014 - Elsevier
Mutations in proteins of the desmosome are associated with arrhythmogenic
cardiomyopathy (AC; also referred to as “ARVC” or “ARVD”). Life-threatening ventricular
arrhythmias often occur in the concealed phase of the disease before the onset of structural
changes. Among the various potential mechanisms for arrhythmogenesis in AC, in this
article, we concentrate on the relation between desmosomes and sodium channel function.
We review evidence indicating that (1) loss of desmosomal integrity (including mutations or …
cardiomyopathy (AC; also referred to as “ARVC” or “ARVD”). Life-threatening ventricular
arrhythmias often occur in the concealed phase of the disease before the onset of structural
changes. Among the various potential mechanisms for arrhythmogenesis in AC, in this
article, we concentrate on the relation between desmosomes and sodium channel function.
We review evidence indicating that (1) loss of desmosomal integrity (including mutations or …