[HTML][HTML] FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats [S]
The farnesoid X receptor (FXR) is a bile acid activated nuclear receptor. Zucker (fa/fa) rats,
harboring a loss of function mutation of the leptin receptor, develop diabetes, insulin
resistance, obesity, and liver steatosis. In this study, we investigated the effect of FXR
activation by 6-ethyl-chenodeoxycholic acid,(6E-CDCA, 10 mg/kg) on insulin resistance and
liver and muscle lipid metabolism in fa/fa rats and compared its activity with rosiglitazone (10
mg/kg) alone or in combination with 6E-CDCA (5 mg/kg each). In comparison to lean (fa/+) …
harboring a loss of function mutation of the leptin receptor, develop diabetes, insulin
resistance, obesity, and liver steatosis. In this study, we investigated the effect of FXR
activation by 6-ethyl-chenodeoxycholic acid,(6E-CDCA, 10 mg/kg) on insulin resistance and
liver and muscle lipid metabolism in fa/fa rats and compared its activity with rosiglitazone (10
mg/kg) alone or in combination with 6E-CDCA (5 mg/kg each). In comparison to lean (fa/+) …