[HTML][HTML] Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

GT Wong, D Manfra, FM Poulet, Q Zhang… - Journal of Biological …, 2004 - ASBMB
Inhibition of γ-secretase, one of the enzymes responsible for the cleavage of the amyloid
precursor protein (APP) to produce the pathogenic β-amyloid (Aβ) peptides, is an attractive
approach to the treatment of Alzheimer disease. In addition to APP, however, several other γ-
secretase substrates have been identified (eg Notch), and altered processing of these
substrates by γ-secretase inhibitors could lead to unintended biological consequences. To
study the in vivo consequences of γ-secretase inhibition, the γ-secretase inhibitor LY …