Regulation of chemokine receptor expression in human microglia and astrocytes
G Flynn, S Maru, J Loughlin, IA Romero… - Journal of …, 2003 - Elsevier
It has been proposed that the positioning of mobile cells within a tissue is determined by
their overall profile of chemokine receptors. This study examines the profiles of chemokine
receptors expressed on resting and activated adult human microglial cells, astrocytes and a
microglial cell line, CHME3. Microglia express highest levels of CXCR1, CXCR3 and CCR3.
Astrocytes also have moderate levels of CXCR1 and CXCR3, and some CCR3, while both
cell types also expressed CCR4, CCR5, CCR6, CXCR2, CXCR4 and CXCR5 at lower …
their overall profile of chemokine receptors. This study examines the profiles of chemokine
receptors expressed on resting and activated adult human microglial cells, astrocytes and a
microglial cell line, CHME3. Microglia express highest levels of CXCR1, CXCR3 and CCR3.
Astrocytes also have moderate levels of CXCR1 and CXCR3, and some CCR3, while both
cell types also expressed CCR4, CCR5, CCR6, CXCR2, CXCR4 and CXCR5 at lower …