[HTML][HTML] Role of calcium-independent phospholipase A2β in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle …
Previous studies suggest that high glucose-induced RhoA/Rho kinase/CPI-17 activation is
involved in diabetes-associated vascular smooth muscle hypercontractility. However, the
upstream signaling that links high glucose and RhoA/Rho kinase/CPI-17 activation is
unknown. Here we report that calcium-independent phospholipase A 2 β (iPLA 2 β) is
required for high glucose-induced RhoA/Rho kinase/CPI-17 activation and thereby
contributes to diabetes-associated vascular smooth muscle hypercontractility. We …
involved in diabetes-associated vascular smooth muscle hypercontractility. However, the
upstream signaling that links high glucose and RhoA/Rho kinase/CPI-17 activation is
unknown. Here we report that calcium-independent phospholipase A 2 β (iPLA 2 β) is
required for high glucose-induced RhoA/Rho kinase/CPI-17 activation and thereby
contributes to diabetes-associated vascular smooth muscle hypercontractility. We …