Small ubiquitin‐related modifiers: a novel and independent class of autoantigens in primary biliary cirrhosis
C Janka, C Selmi, ME Gershwin, H Will, T Sternsdorf - Hepatology, 2005 - journals.lww.com
Serum autoantibodies against components of nuclear dots (anti-NDs), namely PML and
Sp100, are specifically detected in 20% to 30% of patients with primary biliary cirrhosis
(PBC). Although anti-ND antibodies are nonpathogenic, the mechanisms that lead to this
unique reactivity are critical to understanding the loss of immune tolerance in PBC.
Importantly, Sp100 and PML are both covalently linked to small ubiquitin-related modifiers
(SUMOs). Therefore, we investigated whether SUMO proteins are independent autoantigens …
Sp100, are specifically detected in 20% to 30% of patients with primary biliary cirrhosis
(PBC). Although anti-ND antibodies are nonpathogenic, the mechanisms that lead to this
unique reactivity are critical to understanding the loss of immune tolerance in PBC.
Importantly, Sp100 and PML are both covalently linked to small ubiquitin-related modifiers
(SUMOs). Therefore, we investigated whether SUMO proteins are independent autoantigens …