The use of an anti-CD3 immunotoxin to prevent the development of lymphoproliferative disease in SCID/PBL mice
B Clinchy, ES Vitetta - Journal of immunological methods, 1998 - Elsevier
Severe combined immunodeficient mice (SCID) reconstituted with normal PBLs (SCID/PBL)
from Epstein-Barr virus-positive (EBV+) human donors often develop fatal human B
lymphomas which resemble the EBV-induced lymphoproliferative disease (LPD) observed
in immunosuppressed individuals. This phenomenon appears to be T cell dependent. In this
study we used an immunotoxin (IT) prepared by conjugating the monoclonal anti-CD3
antibody, 64.1, to deglycosylated ricin A chain (dgRTA) to prevent LPD in SCID/PBL mice …
from Epstein-Barr virus-positive (EBV+) human donors often develop fatal human B
lymphomas which resemble the EBV-induced lymphoproliferative disease (LPD) observed
in immunosuppressed individuals. This phenomenon appears to be T cell dependent. In this
study we used an immunotoxin (IT) prepared by conjugating the monoclonal anti-CD3
antibody, 64.1, to deglycosylated ricin A chain (dgRTA) to prevent LPD in SCID/PBL mice …