Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension
KM Thompson, N Uetani, C Manitt, M Elchebly… - Molecular and Cellular …, 2003 - Elsevier
Transgenic mice lacking receptor protein tyrosine phophatase-σ (RPTPσ), a type IIa receptor
protein tyrosine phosphatase, exhibit severe neural developmental deficits. Continued
expression of RPTPσ in the adult suggests that it plays a functional role in the mature
nervous system. To determine if RPTPσ might influence axonal regeneration, the time
course of regeneration following facial nerve crush in wild-type and RPTPσ (−/−) mice was
compared. Mice lacking RPTPσ exhibited an accelerated rate of functional recovery …
protein tyrosine phosphatase, exhibit severe neural developmental deficits. Continued
expression of RPTPσ in the adult suggests that it plays a functional role in the mature
nervous system. To determine if RPTPσ might influence axonal regeneration, the time
course of regeneration following facial nerve crush in wild-type and RPTPσ (−/−) mice was
compared. Mice lacking RPTPσ exhibited an accelerated rate of functional recovery …