Indoxyl sulfate induces nephrovascular senescence
T Niwa, H Shimizu - Journal of Renal Nutrition, 2012 - Elsevier
Indoxyl sulfate is markedly accumulated in the serum of chronic kidney disease (CKD)
patients. The oral sorbent AST-120 reduces serum levels of indoxyl sulfate in CKD patients
by adsorbing indole, a precursor of indoxyl sulfate, in the intestine. Indoxyl sulfate is taken
up by proximal tubular cells through organic anion transporters (OAT1, OAT3), and it
induces reactive oxygen species (ROS) with impairment of cellular antioxidative system.
Indoxyl sulfate stimulates progression of CKD by increasing renal expression of profibrotic …
patients. The oral sorbent AST-120 reduces serum levels of indoxyl sulfate in CKD patients
by adsorbing indole, a precursor of indoxyl sulfate, in the intestine. Indoxyl sulfate is taken
up by proximal tubular cells through organic anion transporters (OAT1, OAT3), and it
induces reactive oxygen species (ROS) with impairment of cellular antioxidative system.
Indoxyl sulfate stimulates progression of CKD by increasing renal expression of profibrotic …