[HTML][HTML] Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion
R Van Der Burgh, L Nijhuis, K Pervolaraki… - Journal of Biological …, 2014 - ASBMB
Most hereditary periodic fever syndromes are mediated by deregulated IL-1β secretion. The
generation of mature IL-1β requires two signals: one that induces synthesis of
inflammasome components and substrates and a second that activates inflammasomes. The
mechanisms that mediate autoinflammation in mevalonate kinase deficiency, a periodic
fever disease characterized by a block in isoprenoid biosynthesis, are poorly understood. In
studying the effects of isoprenoid shortage on IL-1 β generation, we identified a new …
generation of mature IL-1β requires two signals: one that induces synthesis of
inflammasome components and substrates and a second that activates inflammasomes. The
mechanisms that mediate autoinflammation in mevalonate kinase deficiency, a periodic
fever disease characterized by a block in isoprenoid biosynthesis, are poorly understood. In
studying the effects of isoprenoid shortage on IL-1 β generation, we identified a new …