[HTML][HTML] Differential involvement of Atg16L1 in Crohn disease and canonical autophagy
A single nucleotide polymorphism in Atg16L1, an autophagy-related gene (ATG), is a risk
factor for Crohn disease, a major form of chronic inflammatory bowel disease. However, it is
still unknown how the Atg16L1 variant contributes to disease development. The Atg16L1
protein possesses a C-terminal WD repeat domain whose function is entirely unknown, and
the Crohn disease-associated mutation (T300A) is within this domain. To elucidate the
function of the WD repeat domain, we established an experimental system in which a WD …
factor for Crohn disease, a major form of chronic inflammatory bowel disease. However, it is
still unknown how the Atg16L1 variant contributes to disease development. The Atg16L1
protein possesses a C-terminal WD repeat domain whose function is entirely unknown, and
the Crohn disease-associated mutation (T300A) is within this domain. To elucidate the
function of the WD repeat domain, we established an experimental system in which a WD …