[HTML][HTML] Autophagy modulation as a potential therapeutic target for diverse diseases

DC Rubinsztein, P Codogno, B Levine - Nature reviews Drug discovery, 2012 - nature.com
Nature reviews Drug discovery, 2012nature.com
Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It
begins when double-membraned autophagosomes engulf portions of the cytoplasm, which
is followed by fusion of these vesicles with lysosomes and degradation of the autophagic
contents. In addition to its vital homeostatic role, this degradation pathway is involved in
various human disorders, including metabolic conditions, neurodegenerative diseases …
Abstract
Autophagy is an essential, conserved lysosomal degradation pathway that controls the quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It begins when double-membraned autophagosomes engulf portions of the cytoplasm, which is followed by fusion of these vesicles with lysosomes and degradation of the autophagic contents. In addition to its vital homeostatic role, this degradation pathway is involved in various human disorders, including metabolic conditions, neurodegenerative diseases, cancers and infectious diseases. This article provides an overview of the mechanisms and regulation of autophagy, the role of this pathway in disease and strategies for therapeutic modulation.
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