[HTML][HTML] Inhibition of mTOR kinase by AZD8055 can antagonize chemotherapy-induced cell death through autophagy induction and down-regulation of p62 …
S Huang, ZJ Yang, C Yu, FA Sinicrope - Journal of Biological Chemistry, 2011 - ASBMB
AZD8055 is an ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) that
forms two multiprotein complexes, mTORC1 and mTORC2, and negatively regulates
autophagy. We demonstrate that AZD8055 stimulates and potentiates chemotherapy-
mediated autophagy, as shown by LC3I-II conversion and down-regulation of the ubiquitin-
binding protein p62/sequestosome 1. AZD8055-induced autophagy was pro-survival as
shown by its ability to attenuate cell death and DNA damage (p-H2AX), and to enhance …
forms two multiprotein complexes, mTORC1 and mTORC2, and negatively regulates
autophagy. We demonstrate that AZD8055 stimulates and potentiates chemotherapy-
mediated autophagy, as shown by LC3I-II conversion and down-regulation of the ubiquitin-
binding protein p62/sequestosome 1. AZD8055-induced autophagy was pro-survival as
shown by its ability to attenuate cell death and DNA damage (p-H2AX), and to enhance …