Ancient haplotypes of the HLA Class II region
CK Raymond, A Kas, M Paddock, R Qiu… - Genome …, 2005 - genome.cshlp.org
CK Raymond, A Kas, M Paddock, R Qiu, Y Zhou, S Subramanian, J Chang, A Palmieri…
Genome Research, 2005•genome.cshlp.orgAllelic variation in codons that specify amino acids that line the peptide-binding pockets of
HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply
diverged haplotypes. These haplotypes appear to have been evolving almost independently
for tens of millions of years. By complete resequencing of 20 haplotypes across the∼ 100-
kbp region that spans the HLA-DQA1,-DQB1, and-DRB1 genes, we provide a detailed view
of the way in which the genome structure at this locus has been shaped by the interplay of …
HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply
diverged haplotypes. These haplotypes appear to have been evolving almost independently
for tens of millions of years. By complete resequencing of 20 haplotypes across the∼ 100-
kbp region that spans the HLA-DQA1,-DQB1, and-DRB1 genes, we provide a detailed view
of the way in which the genome structure at this locus has been shaped by the interplay of …
Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the ∼100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.
genome.cshlp.org