[HTML][HTML] HLA-DR Chains Enter into an Aggregated Complex Containing GRP-78/BiP Prior to Their Degradation by the Pre-Golgi Degradative Pathway (∗)
T Cotner, D Pious - Journal of Biological Chemistry, 1995 - ASBMB
HLA class II molecules are membrane proteins which are assembled in the endoplasmic
reticulum shortly after synthesis of the α and β and invariant chain (Ii) monomers. DRβ
chains, in the absence of DRα, are rapidly and completely degraded by the pre-Golgi
degradative pathway. Here we have examined those factors which target DRβ chains for
degradation in a DRα deficient cell line, 9.22. 3. The DRβ monomers in 9.22. 3 were initially
incorporated into a proteinaceous complex containing BiP. With time, the DRβ complexes …
reticulum shortly after synthesis of the α and β and invariant chain (Ii) monomers. DRβ
chains, in the absence of DRα, are rapidly and completely degraded by the pre-Golgi
degradative pathway. Here we have examined those factors which target DRβ chains for
degradation in a DRα deficient cell line, 9.22. 3. The DRβ monomers in 9.22. 3 were initially
incorporated into a proteinaceous complex containing BiP. With time, the DRβ complexes …