[HTML][HTML] Structural characteristics of HLA-DQ that may impact DM editing and susceptibility to type-1 diabetes
Z Zhou, PE Jensen - Frontiers in Immunology, 2013 - frontiersin.org
Z Zhou, PE Jensen
Frontiers in Immunology, 2013•frontiersin.orgAutoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D),
in which multiple environmental and genetic factors are involved. The association of HLA,
especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular
mechanisms are poorly understood. In this review, we explore the structural characteristics
of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of
autoreactive T cell development in T1D.
in which multiple environmental and genetic factors are involved. The association of HLA,
especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular
mechanisms are poorly understood. In this review, we explore the structural characteristics
of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of
autoreactive T cell development in T1D.
Autoreactive CD4+ T cells initiate the chronic autoimmune disease Type-1 diabetes (T1D), in which multiple environmental and genetic factors are involved. The association of HLA, especially the DR-DQ loci, with risk for T1D is well documented. However, the molecular mechanisms are poorly understood. In this review, we explore the structural characteristics of HLA-DQ and the role of HLA-DM function as they may contribute to an understanding of autoreactive T cell development in T1D.
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