[HTML][HTML] Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

A Hamacher-Brady, NR Brady, RA Gottlieb - Journal of Biological Chemistry, 2006 - ASBMB
Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R).
One feature of I/R injury is the increased presence of autophagosomes. However, to date it
is not known whether macroautophagy functions as a protective pathway, contributes to
programmed cell death, or is an irrelevant event during cardiac I/R injury. We employed
simulated I/R of cardiac HL-1 cells as an in vitro model of I/R injury to the heart. To assess
macroautophagy, we quantified autophagosome generation and degradation (autophagic …