[HTML][HTML] Defective autophagy leads to cancer
AL Edinger, CB Thompson - Cancer cell, 2003 - cell.com
Cancer cell, 2003•cell.com
Cellular proteins are degraded within two distinct compartments: the proteasome and the
lysosome. Alterations in proteasomal degradation can contribute to carcinogenesis. In
contrast, alterations in autophagic protein degradation through the lysosome have not been
linked to cancer. Now two reports demonstrate that the autophagic gene, Beclin 1, is a
haploinsufficient tumor suppressor gene. These new data suggest that autophagic
degradation provides an important mechanism to prevent cellular transformation.
lysosome. Alterations in proteasomal degradation can contribute to carcinogenesis. In
contrast, alterations in autophagic protein degradation through the lysosome have not been
linked to cancer. Now two reports demonstrate that the autophagic gene, Beclin 1, is a
haploinsufficient tumor suppressor gene. These new data suggest that autophagic
degradation provides an important mechanism to prevent cellular transformation.
Abstract
Cellular proteins are degraded within two distinct compartments: the proteasome and the lysosome. Alterations in proteasomal degradation can contribute to carcinogenesis. In contrast, alterations in autophagic protein degradation through the lysosome have not been linked to cancer. Now two reports demonstrate that the autophagic gene, Beclin 1, is a haploinsufficient tumor suppressor gene. These new data suggest that autophagic degradation provides an important mechanism to prevent cellular transformation.
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