Strong evidence exists for a link between chronic low level inflammation and dietary-
induced insulin resistance; however, little is known about the transcriptional networks
involved. Here we show that high fat diet (HFD) or saturated fatty acid exposure directly
activates CCAAT/enhancer-binding protein β (C/EBPβ) protein expression in liver,
adipocytes, and macrophages. Global C/EBPβ deletion prevented HFD-induced
inflammation and surprisingly increased mitochondrial gene expression in white adipose …