Context Basic research and observational studies suggest vitamin E or vitamin C may
reduce the risk of cardiovascular disease. However, few long-term trials have evaluated men
at initially low risk of cardiovascular disease, and no previous trial in men has examined
vitamin C alone in the prevention of cardiovascular disease. Objective To evaluate whether
long-term vitamin E or vitamin C supplementation decreases the risk of major cardiovascular
events among men. Design, Setting, and Participants The Physicians' Health Study II was a …