[HTML][HTML] Transport of cyclic nucleotides and estradiol 17-β-D-glucuronide by multidrug resistance protein 4
ZS Chen, K Lee, GD Kruh - Journal of Biological Chemistry, 2001 - ASBMB
Human multidrug resistance protein 4 (MRP4) has recently been determined to confer
resistance to the antiviral purine analog 9-(2-phosphonylmethoxyethyl) adenine and
methotrexate. However, neither its substrate selectivity nor physiological functions have
been determined. Here we report the results of investigations of thein vitro transport
properties of MRP4 using membrane vesicles prepared from insect cells infected with MRP4
baculovirus. It is shown that expression of MRP4 is specifically associated with the MgATP …
resistance to the antiviral purine analog 9-(2-phosphonylmethoxyethyl) adenine and
methotrexate. However, neither its substrate selectivity nor physiological functions have
been determined. Here we report the results of investigations of thein vitro transport
properties of MRP4 using membrane vesicles prepared from insect cells infected with MRP4
baculovirus. It is shown that expression of MRP4 is specifically associated with the MgATP …