Follicular lymphoma (FL) pathogenesis is a complex and fascinating multi-hit process,
escalating along successive derailments of the distinctive molecular and cellular
mechanisms paving B-cell differentiation and activation. This progressive subversion of B-
cell receptor diversification mechanisms and B-cell homeostasis likely occurs during a
protracted preclinical phase of asymptomatic growth, in which premalignant clones already
disseminate and establish “niches” in secondary lymphoid organs. Following FL diagnosis …