[HTML][HTML] Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κB signaling pathway
PC Lucas, M Yonezumi, N Inohara… - Journal of Biological …, 2001 - ASBMB
At least two distinct recurrent chromosomal translocations have been implicated in the
pathogenesis of MALT lymphoma. The first, t (1; 14), results in the transfer of the entireBcl10
gene to chromosome 14 wherein Bcl10 expression is inappropriately stimulated by the
neighboring Ig enhancer. The second, t (11; 18), results in the synthesis of a novel fusion
protein, API2-MALT1. Until now, no common mechanism of action has been proposed to
explain how the products of these seemingly unrelated translocations may contribute to the …
pathogenesis of MALT lymphoma. The first, t (1; 14), results in the transfer of the entireBcl10
gene to chromosome 14 wherein Bcl10 expression is inappropriately stimulated by the
neighboring Ig enhancer. The second, t (11; 18), results in the synthesis of a novel fusion
protein, API2-MALT1. Until now, no common mechanism of action has been proposed to
explain how the products of these seemingly unrelated translocations may contribute to the …