Multifunctional roles for MALT1 in T-cell activation

M Thome - Nature Reviews Immunology, 2008 - nature.com
Nature Reviews Immunology, 2008nature.com
The activation of T cells is vital to the successful elimination of pathogens, but can also have
a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are
triggered by the T-cell receptor; these have key roles in the control of the T-cell response
and represent interesting targets for therapeutic immunomodulation. Recent findings define
MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein
with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell …
Abstract
The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways.
nature.com