[HTML][HTML] IKK-i/IKKϵ controls constitutive, cancer cell-associated NF-κB activity via regulation of Ser-536 p65/RelA phosphorylation
M Adli, AS Baldwin - Journal of biological chemistry, 2006 - ASBMB
Nuclear factor κB (NF-κB) has been studied extensively as an inducible transcriptional
regulator of the immune and inflammatory response. NF-κB activation downstream of
lipopolysaccharide or cytokine stimulation is controlled by the IκB kinase complex, which
contains IKKα and IKKβ. Significantly, the constitutive activity of NF-κB has been implicated
as an important aspect of many cancer cells, but mechanisms associated with this activity
are poorly understood. An inducible kinase, IKK-i/IKKϵ, related to the catalytic forms of the …
regulator of the immune and inflammatory response. NF-κB activation downstream of
lipopolysaccharide or cytokine stimulation is controlled by the IκB kinase complex, which
contains IKKα and IKKβ. Significantly, the constitutive activity of NF-κB has been implicated
as an important aspect of many cancer cells, but mechanisms associated with this activity
are poorly understood. An inducible kinase, IKK-i/IKKϵ, related to the catalytic forms of the …