[HTML][HTML] Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of …
LM Grove, BD Southern, TH Jin, KE White… - Journal of Biological …, 2014 - ASBMB
The urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol-
linked membrane protein with no cytosolic domain that localizes to lipid raft microdomains.
Our laboratory and others have documented that lung fibroblasts from patients with
idiopathic pulmonary fibrosis (IPF) exhibit a hypermotile phenotype. This study was
undertaken to elucidate the molecular mechanism whereby uPAR ligation with its cognate
ligand, urokinase, induces a motile phenotype in human lung fibroblasts. We found that …
linked membrane protein with no cytosolic domain that localizes to lipid raft microdomains.
Our laboratory and others have documented that lung fibroblasts from patients with
idiopathic pulmonary fibrosis (IPF) exhibit a hypermotile phenotype. This study was
undertaken to elucidate the molecular mechanism whereby uPAR ligation with its cognate
ligand, urokinase, induces a motile phenotype in human lung fibroblasts. We found that …