The renal cell primary cilium functions as a flow sensor
HA Praetorius, KR Spring - Current opinion in nephrology and …, 2003 - journals.lww.com
HA Praetorius, KR Spring
Current opinion in nephrology and hypertension, 2003•journals.lww.comThe primary cilium is mechanically sensitive and serves as a flow sensor in cultured renal
epithelia. Bending the cilium by mechanical means or flow causes a large, prolonged
transient increase in intracellular calcium. The mechanically sensitive protein in the cilium is
a polycystin.
epithelia. Bending the cilium by mechanical means or flow causes a large, prolonged
transient increase in intracellular calcium. The mechanically sensitive protein in the cilium is
a polycystin.
Summary
The primary cilium is mechanically sensitive and serves as a flow sensor in cultured renal epithelia. Bending the cilium by mechanical means or flow causes a large, prolonged transient increase in intracellular calcium. The mechanically sensitive protein in the cilium is a polycystin.
Lippincott Williams & Wilkins